David P. Giedroc

David P. Giedroc

Professor and Chair

Divisions

David Giedroc graduated from the Pennsylvania State University in 1980 with a B.S. in Biochemistry. After a brief stint in Joseph Villafranca's group at Penn State working on active site inhibitors of the copper metalloenzyme dopamine-ß-hydroxylase, he earned a Ph.D. in Biochemistry at Vanderbilt University in 1984, where he worked with David Puett on the vertebrate calcium sensor calmodulin. From 1984-1988, he was an NIH postdoctoral fellow in the late Joseph E. Coleman's laboratory at Yale University, where he worked on zinc-containing DNA binding proteins. From 1988-2007, Dr. Giedroc was a member of the faculty in the Department of Biochemistry and Biophysics at Texas A&M University.

In 2007, he became Professor of Chemistry at Indiana University where he has continued his studies of transcriptional metalloregulatory proteins, with a particular focus of zinc- and copper-specific metal sensor proteins from bacterial pathogens, translational frameshifting, and RNA structure and function in mammalian coronavirus replication. His discovery and characterization of a new family of copper metalloregulators was highlighted in Chemical & Engineering News in December 2006. Dr. Giedroc seeks a physicochemical understanding of macromolecular structure and regulation, and uses the tools of biophysical chemistry, bioinorganic chemistry, chemical biology and NMR structure determination.